There’s been a lot of talk about alternate tests to get more info about UVA/DNA damage by sun. This looks as promising as all the rest, but it’s going to take a lot more testing to determine if these responses intensify in proportion to exposure, how universal the responses are, and how this might translate into a reproducible, quantifiable test.
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Investigating p53 expression could enhance sunscreen efficacy tests
By Katie Bird, 20-Jan-2009

Looking directly at the expression of the p53 gene may be a more accurate way of testing how well a sunscreen protects against UV damage, according to a recent study.

Currently the sunscreen industry uses an SPF (Sun Protection Factor) value to communicate the efficacy of a product to consumers.

However, SPF is a measure of the protection against UVB-induced erythema (skin reddening) and says nothing about protecting against UVA rays, or the actual UV-induced DNA damage.

Now a recent report published in the latest edition of the International Journal of Dermatology suggests an in vivo test using p53 expression as a way of judging sunscreen efficacy.

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